Warning:
JavaScript is turned OFF. None of the links on this page will work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Case 3-3 Gout, release of norepinephrine slow mechanism release of alpha2 AR, Recruits Macrophage Activity Phagocytosis of x-tals releases TNF alpha, IL1, IL8 and PGE2, Dehydration + ringclosure Inosine Monophosphate, Immune response Nociceptive Pain Potentiation, Increase phosphorylation of Voltage gated Na channels Potentiation of nociceptor excitability, Gout High levels of Serum Uric Acid, Inceased Anion exchange of URAT 1 transporter Increase urate resorption, Mast Cells/ platelets Seratonin release, Activation of PKA Increase phosphorylation of Voltage gated Na channels, Acttracts Neutrophil extravastaion Neutrophil Activity: Phagocytosis Degranulation Free radiacal generation release of proteases, Nervous stimulation to create central prostaglandin stimulates vagus nerve in liver, Increase urate resorption Hyperurecemia, Enhanced tubular resorption Drug induced potentiation of Urate resorption, Diminshed Renal Function Uric Acid Nephrolithiasis, Bradykinin released Binds to B1 receptors on somatic nociceptors, Over Producers HGPRT error Abnormal Salvage uses PRPP makes nucleotides, Acetoacteate Increased intraepithelial monoaninon [], High Serum Uric acid Gout, Chemokine activity Stimulation of Mast cells, basophils, platelets, High Serum Uric acid ? Hx of Kidney stones